解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Enzyme-inducing drugs such as phenobarbital (PB) increase serum concentrations of an acute-phase protein, alpha 1-acid glycoprotein (AGP), in man, dogs, and rats via an unknown mechanism. We studied the effects of PB on components of an acute inflammatory reaction in rats in order to determine if PB acts only on this ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00923344
更新日期:1991-12-01 00:00:00
abstract::Genetic messages for polypeptide growth factors were assessed in human alveolar macrophages, obtained by bronchoalveolar lavage (BAL) from normal subjects (N = 3) and from patients with pneumonia (N = 3), pulmonary lymphoma (N = 3), and idiopathic pulmonary fibrosis (N = 3). Complementary DNAs (cDNAs) were prepared by...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00917311
更新日期:1991-08-01 00:00:00
abstract::Polymorphonuclear neutrophil (PMN) function is thought to be critical in resistance to infectious agents and this implies that the PMN must be able to migrate into, and to function in, environments that may have high levels of bacterial lipopolysaccharide (LPS). Therefore, we have evaluated the effect of LPS on the in...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00918646
更新日期:1991-06-01 00:00:00
abstract::Thromboxane (Tx) A2 generation and subsequent selective pulmonary sequestration of neutrophils (PMNs) is characteristic of several forms of the adult respiratory distress syndrome (ARDS). Therefore, we examined PMN-dependent adhesion to cultured pulmonary microvessel and aortic endothelium (EC) in response to U46,619 ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00918645
更新日期:1991-06-01 00:00:00
abstract::Previous data that alimentation with fish oil rich in eicosapentaenoic acid (EPA; 20:n-3) or vegetable oil rich in gamma-linolenic acid (GLA; 18:3n-6) can reduce symptoms of inflammatory skin disorders lead us to determine the effects of dietary supplements of oils rich in EPA or GLA on guinea pig (GP) neutrophil (PMN...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00914278
更新日期:1990-10-01 00:00:00
abstract::Both recombinant IL-1 alpha and -beta caused an upregulation of C3b receptors (CR1) on human neutrophils and caused a receptor-mediated enhancement of phagocytosis of C3b.IgG-coated microspheres by these leukocytes. The alpha and beta forms of the recombinant cytokine were of comparable potency regarding CR1 upregulat...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00917457
更新日期:1990-04-01 00:00:00
abstract::Multiple forms of soluble phospholipase A2 (PLA2) are known to coexist in venoms of individual reptilian species. While similar observations in several mammalian species suggest that this is a common phenomenon, the functional implications are not yet understood. In attempting to devise therapeutic strategies for trea...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00917456
更新日期:1990-04-01 00:00:00
abstract::High concentrations of corticosteroids inhibit granulocyte responses and disrupt agonist receptor function. Dose-response and time-course considerations make it unlikely that these effects are mediated via the glucocorticoid receptor, a concept further supported by the ability of sex steroids to work similar effects. ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00914030
更新日期:1990-02-01 00:00:00
abstract::The role of peptide leukotrienes (p-LTs), especially LTC4 and LTD4 in liver disease, was investigated in mice experimental liver injury models. The liver injury was induced by the injection of bacterial lipopolysaccharide (LPS) into Corynebacterium parvum pretreated mice. Carbon tetrachloride (CCl4)-induced liver inju...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00914311
更新日期:1989-12-01 00:00:00
abstract::Increased susceptibility of neonates to infection may be related to defects in newborn neutrophil (PMN) functional activities, including altered responses to complement fragments (Cf) and defective microbicidal activity. We therefore compared the kinetics of newborn and adult bovine PMN membrane shape change responses...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00914305
更新日期:1989-12-01 00:00:00
abstract::Recombinant human interleukin-1 beta (IL-1) and tumor necrosis factor-alpha (TNF) synergistically stimulated BALB/c 3T3 cells to produce a chemotactic factor for rat polymorphonuclear leukocytes (PMNs), whereas an addition of 10(-11)-10(-8) M IL-1 or TNF alone to the cell culture resulted in a slight increase in the p...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00916761
更新日期:1989-10-01 00:00:00
abstract::Using crossed immunoelectrophoresis, immunoelectrodiffusion, autoradiography, and equilibrium binding techniques, we demonstrate that the rat fetus, directly challenged in utero at 18 days by a single subcutaneous turpentine injection, presents a complex acute-phase plasma inflammatory response. A number of fetal seru...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00918965
更新日期:1989-02-01 00:00:00
abstract::Human neutrophils (PMNs) which have been incubated with lipoteichoic acid (LTA) from group A streptococci generated large amounts of superoxide (O2- chemiluminescence and hydrogen peroxide when challenged with anti-LTA antibodies. Cytochalasin B further enhanced O2- generation. The onset of O2- generation by the LTA-a...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00914316
更新日期:1988-12-01 00:00:00
abstract::Diets enriched in omega-3 fatty acids exert antiinflammatory properties by suppressing some neutrophil (PMN) functions. Changes in cytosolic Ca2+ concentration, [Ca2+]i, are important for PMN activation and are in part regulated by membrane Ca2+ ATPases. Since membrane proteins are influenced by their lipid environmen...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00919440
更新日期:1988-10-01 00:00:00
abstract::Four methods of severe disruption of human neutrophil membrane integrity resulted in the formation of substantial amounts of leukotriene B4 and its isomers. This synthesis took place from endogenous substrate in the absence of any cell activators. It is postulated that leukotriene formation could be a preserved cell f...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00916396
更新日期:1988-04-01 00:00:00
abstract::Recent studies have demonstrated that a calcium-sensitive protease converts Ca2+/phospholipid-dependent protein kinase C to a Ca2+/phospholipid-independent form during the activation of human neutrophils. In this paper, the results of the purification and characterization of a calcium-dependent cytosolic protease from...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00915892
更新日期:1988-02-01 00:00:00
abstract::Comparison of the physiologic responses in rabbits to the intravenous infusion of two polymorphonuclear neutrophil (PMN) activators, N-formyl-methionyl-leucyl-phenylalanine (FMLP) and phorbol myristate acetate (PMA), has revealed marked differences in kinetics for activation between these agents. FMLP infusion was ass...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00915990
更新日期:1987-12-01 00:00:00
abstract::Pig alveolar macrophages are a heterogeneous population of cells. Three subpopulations or bands exist when the whole population is separated according to density. Band 1 cells are the least dense cells and constitute 9% of the total population. Bands 2 and 3 represent 44 and 47% of the total population. The three subp...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00915841
更新日期:1987-09-01 00:00:00
abstract::Slow translocation of protein kinase C was observed by both auranofin and gold sodium thiomalate pretreatment of neutrophils. Both gold compounds failed to influence the activity of this enzyme directly when cell-free studies were performed. In intact neutrophils incubated with 5.1-20.3 microM auranofin, protein kinas...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00915842
更新日期:1987-09-01 00:00:00
abstract::Rheumatoid synovial fluids generated significantly greater amounts of superoxide, lysosomal enzymes, and superoxide dismutase from neutrophils into extracellular fluid than osteoarthritic synovial fluids. Rheumatoid factors isolated from serum suppressed superoxide-generating activity of performed immune complexes, bu...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00916016
更新日期:1987-06-01 00:00:00
abstract::Protamine sulfate induces enzyme secretion from rabbit neutrophils. Enzyme secretion is mainly due to exocytosis but, depending on the experimental conditions, a small amount of cytolysis may occur. As compared with stimulation of neutrophil functions by other activators, protamine sulfate-induced enzyme release by ex...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00915825
更新日期:1986-12-01 00:00:00
abstract::Leukocyte chemoattractants markedly alter the morphology and membrane functions of leukocytes. Bacterial collagenase causes a change in cell shape similar to that seen with the leukocyte chemoattractant, f-Met-Leu-Phe, and also promotes capping of concanavalin A. Human neutrophils in suspension or adherent to cover gl...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00915819
更新日期:1986-12-01 00:00:00
abstract::Bee venom (BV) is used in folk medicine to treat arthritis. It has antiinflammatory effects in animal models of rheumatic disease. We have studied the effects of BV on human neutrophil production of superoxide (O2-) and hydrogen peroxide, finding potent, nontoxic, dose-dependent production inhibition. Melittin, the ma...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00915999
更新日期:1986-06-01 00:00:00
abstract::The levels of mRNA for plasma proteins and for metallothionein in rat liver during the acute-phase response were studied by hybridization to specific cDNA probes. The mRNA for alpha 2-macroglobulin, the beta-chain of fibrinogen, alpha 1-acid glycoprotein (so-called acute-phase reactants) reached a maximum level betwee...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00916041
更新日期:1986-03-01 00:00:00
abstract::Human blood leukocytes generated large amounts of superoxide (O2-) following stimulation by certain "cocktails" of soluble agents consisting of poly-L-arginine (PARG), phytohemagglutinin, the chemotactic peptide formyl-methionyl-leucyl-phenylalanine and polyanethole sulfanote (liquoid). A variety of cytochalasins, whi...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00916335
更新日期:1985-12-01 00:00:00
abstract::The purpose of this study was to evaluate the rabbit anterior eye chamber as a quantitative measure of leukotaxis using 51Cr-labeled homologous leukocytes and then to determine the effects of ibuprofen on N-formyl-methionyl-leucyl-phenylalanine (FMLP) -induced leukotaxis. Leukocyte accumulation was assessed at various...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00916277
更新日期:1985-09-01 00:00:00
abstract::By the use of the nuclear microprobe technique, the concentrations of zinc in isolated erythrocytes, platelets, and granulocytes were measured in patients with rheumatoid arthritis, other inflammatory arthritides, and scleroderma. Markedly reduced cellular zinc values were found compared to those measured in healthy s...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00917591
更新日期:1985-06-01 00:00:00
abstract::C3b receptor (CR1) expression by neutrophils (PMNs) and erythrocytes (Es) from patients with chronic granulomatous disease (CGD) or with hyper-IgE, frequent infection (Job's) syndrome was compared with that of control subjects. The control subjects consisted of one group of patients with infections and a second group ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00918218
更新日期:1984-12-01 00:00:00
abstract::A variety of steroidal and nonsteroidal antiinflammatory agents (NSAs) were compared for their effectiveness against a developing acute inflammatory reaction. Only BW 755C [3-amino-1-(m-trifluoromethyl)-phenyl-2-pyrazole] was immediately effective when administered 2 h after carrageenin, as the 3-h swelling was signif...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00916412
更新日期:1984-09-01 00:00:00
abstract::A full understanding of rheumatoid arthritis depends on the appreciation of clinical, radiological, immunological, genetic, biochemical, and structural mechanisms. Rheumatoid arthritis is characterized by the destruction of tissue structures such as articular cartilage and bone, but may also involve tendonous tissue, ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00915710
更新日期:1984-06-01 00:00:00
abstract::Superoxide dismutase (SOD) is known to regulate the level of superoxide radicals inside cells. The purpose of this work was to investigate the role of SOD activity in tissue damage produced by superoxide radicals. SOD was measured in polymorphonuclear cells of patients with rheumatoid arthritis and controls. The disti...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00918350
更新日期:1984-03-01 00:00:00
abstract::Two methods for quantitating polymorphonuclear leukocyte (PMN) accumulation in inflammatory skin lesions were studied. The lesions were produced in rats by intradermal injections of different dilutions of zymosan-activated plasma (ZAP). PMN accumulation in the skin lesions was estimated by determination of (1) homolog...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00917262
更新日期:1983-09-01 00:00:00
abstract::The respiratory burst is a series of metabolic events which result in the production of microbicidal oxidants by phagocytes. The enzyme responsible for the respiratory burst is a membrane-bound oxidase which catalyzes the production of O-2 by the NADPH-dependent reduction of oxygen. Activity of this oxidase is diminis...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00917260
更新日期:1983-09-01 00:00:00
abstract::In order to establish a model of lung disease in which the usefulness of potential antiinflammatory compounds can be evaluated, we have analyzed the biochemical and cellular responses of rabbits to zymosan deposition in their lungs. A suspension of zymosan particles was instilled into the lungs of rabbits using an int...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00917816
更新日期:1983-06-01 00:00:00
abstract::The effect of leukocyte hydrolytic enzymes on periodontopathic bacteria was examined in vitro. A frozen and thawed extract of human peripheral blood leukocytes (LE) and human gingival crevicular exudate (GE) were shown to be able to cause the release of 50% of the radioactivity from a leukotoxic strain of Actinobacill...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00917824
更新日期:1983-06-01 00:00:00
abstract::We have previously shown that deuterium oxide (D2O) enhances the oxidation of methionine, a myeloperoxidase (MPO) -mediated reaction, by human neutrophils during phagocytosis. However, D2O has no effect on the oxidation of methionine by the purified MPO-H2O2-Cl- system. To explain this observation, we studied the effe...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00917309
更新日期:1982-12-01 00:00:00
abstract::Granulocytes depend on anaerobic glycolysis for the energy required for chemotaxis, phagocytosis, and microbial killing. Two potential sources of the needed glucose are available: exogenous glucose and intracellular glycogen. These studies demonstrate that chemotaxin-induced movement of granulocytes induces accelerate...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00916406
更新日期:1982-09-01 00:00:00
abstract::Stacks of six membrane filters (8-mu pore size) were placed over the mouths of plastic tubes. The tubes were filled with casein (test) or NaCl (control) solution and implanted subcutaneously in white rats; each animal received one tube with casein and one control tube. After 12, 18, 24, and 36 h, the tubes were remove...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00916239
更新日期:1982-06-01 00:00:00
abstract::Two different substances, glycogen and thioglycollate, were used to recruit early peritoneal exudate cells (4h). In the acute phase of the inflammatory response the cellular infiltrate is large, and the predominant cell (greater than 95%) is the polymorphonuclear neutrophil. Supernatant had differing effects on lympho...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00910714
更新日期:1982-03-01 00:00:00
abstract::Prostaglandin production was studied in cultures of pig aorta endothelial cells using radioimmunoassay, radiochromatography, and smooth muscle bioassay. PGE2 was produced in higher concentrations than other prostaglandins. Bradykinin produced a rapid dose-related stimulation of PGE2 production. These results provided ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00911100
更新日期:1981-12-01 00:00:00